MCA revisited [2]

{First posted 8 June 2011 at, saved from oblivion by the internet archive}

As a base example, we’ll use the model presented in [1], a 1986 paper describing METAMOD – modelling software for your BBC micro. How I’d love to have a play with METAMOD now.

The model is called SEQFB, a branched pathway with sequential feedbacks. The program is used to find the model’s steady state for metabolite concentrations

Met Conc Copasi
A 2.2099E1 22.0992
B 4.6395E0 4.63950
C 3.3577E-1 0.335772
D 4.3999E-1 0.439992
E 2.7777E-1 0.277773
F 2.6500E-1 0.264999

and reaction rates.

Enz Rate Copasi
1 1.4261E0 1.42613
2 1.4261E0 1.42613
3 6.9765E-1 0.69753
4 6.9765E-1 0.69753
5 6.9765E-1 0.69753
6 7.2847E-1 0.728472
7 7.2847E-1 0.728472
8 7.2847E-1 0.728472

It’s good to see that loading the model [2] into fancy new software [3] gives identical results. Who needs technology eh? OK, so maybe it runs slightly faster today – half a blink of an eye, rather than just under two minutes.

More tomorrow.

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  1. Hofmeyr JH, & van der Merwe KJ (1986). METAMOD: software for steady-state modelling and control analysis of metabolic pathways on the BBC microcomputer. Computer applications in the biosciences: CABIOS, 2 (4), 243-9 PMID: 3450367
  2. Model v.1 SBML
  3. Copasi

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